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Statistical analyses were performed using GraphPad InStat version 3.00 (GraphPad Software, San Diego, CA) and SAS Enterprise Guide 4.1 (SAS Institute, Cary, NC). Differences were considered statistically significant at P PF-6463922 supplier a metabolic syndrome. During clamp, severely obese subjects showed marked insulin resistance as assessed by decreased insulin-mediated glucose uptake at the expense of both nonoxidative and oxidative glucose disposal (Table 1 and Figure 1a�Cc). This insulin resistance in severely obese women also caused reduced insulin suppression of lipolysis (with higher serum free fatty acids at the end of the clamp) and subsequent higher rates of lipid oxidation (Table 1 and Figure 1d). When normalized for LBM, clamp energy expenditure was decreased in severely obese women compared to lean ones, possibly due to the lower insulin-induced glucose utilization. Serum levels of three out of the five adipokines studied were higher in severely obese women than in lean ones. Epigenetic inhibitors Cefaloridine Thus, when compared to lean women, serum levels of GRO-��, TPO, and TIMP-1 were increased in severely obese subjects by ?30, 55, and 20%, respectively (P